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US 2021/0207102 A1Published application
Virus-like particles co-expressing toxoplasma gondii imc, rop18, and mic8, and pharmaceutical composition comprising the same
AssigneeHealth Park Incorporated
InventorsHyunwoo Park, Hui Jin, Fu Shi Quan
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Abstract
The present invention relates to a virus-like particle for preventing or treating toxoplasmosis, comprising influenza virus matrix protein 1; and surface antigen proteins comprising an inner membrane complex, Rhoptry protein 18 and Microneme protein 8 derived from Toxoplasma gondii, and a pharmaceutical composition comprising the same.
Claims13
A virus-like particle, comprising:
- influenza virus matrix protein 1 (M1);
- and
- surface antigen proteins comprising an inner membrane complex (IMC), Rhoptry protein 18 (ROP18) and Microneme protein 8 (MIC8) derived from Toxoplasma gondii.
An expression vector for preparing a virus-like particle comprising a nucleic acid sequence of GenBank Accession No. EF467824 (SEQ ID NO:
- 5) encoding influenza virus matrix protein 1 (M1);
- a nucleic acid sequence of GenBank Accession No. HQ012579 (SEQ ID NO:
- 6) encoding an inner membrane complex (IMC);
- a nucleic acid sequence of GenBank Accession No. AM075204 (SEQ ID NO:
- 7) encoding Rhoptry protein 18 (ROP18);
- and a nucleic acid sequence of GenBank Accession No. AF353165 (SEQ ID NO:
- 8) encoding Microneme protein 8 (MIC8).
4 more elements
Dependencies are inferred from the claim text.