Core-shell polymer nanoparticle
AssigneeThe University of Queensland
InventorsChunxia ZHAO, Yun LIU
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Abstract
A method of forming a core-shell polymer nanoparticle encapsulating an active agent is disclosed, including the use of a multi-solvent system in which to dissolve the active agent and a polymer prior to their precipitation using an antisolvent. The preferred use of an organic solvent system comprising two or more organic solvents allows for a high degree of control, as compared with the use of a single solvent, and enables the active agent to be precipitated more or less simultaneously with, or just prior to, the polymer.
Claims22
A method of forming a core-shell polymer nanoparticle comprising an active agent including the steps of:
- (a) dissolving a polymer and an active agent in a solvent system, the solvent system comprising at least two organic solvents, to thereby form an active solution;
- (b) mixing the active solution with at least one antisolvent to precipitate the active agent and the polymer;
- and
- (c) allowing the precipitated polymer and active agent to form a core-shell polymer nanoparticle comprising the active agent.
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Dependencies are inferred from the claim text.