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US 2021/0202039 A1Published application
Method for designing optimized mutant protein sequence using amino acid coevolutionary information
AssigneeKorea Institute of Science and Technology
InventorsKeunwan PARK, Cheol-Ho PAN, Moon-Hyeong SEO, Dae-geun SONG, Chulhee KWAK
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Abstract
The present invention relates to a method for designing an optimized mutant protein sequence using amino acid co-evolutionary information. Specifically, the present invention relates to a method for searching a protein having a novel mutant sequence with improved expression level, water solubility, stability, and functionality, while maintaining the original function of the protein, using amino acid co-evolutionary information and information on protein tertiary structure.
Claims13
A method for designing an optimized mutant sequence, comprising
- calculating amino acid co-evolutionary information;
- and
- searching for a mutant sequence with the maximum co-evolution score.
Dependencies are inferred from the claim text.