Delivering enzyme using an injectable hydrogel depot
AssigneeSaint Louis University
InventorsAdriana M. Montaño, Silviya Petrova Zustiak, Era Jain
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Abstract
Compositions and methods for delivering enzymes in enzyme hydrogel formulations are disclosed. More particularly, the present disclosure relates to injectable enzyme hydrogel formulations and delivery of injectable enzyme hydrogel formulations. Also disclosed are methods for GALNS enzyme replacement therapy and lysosomal enzyme replacement therapy.
Claims19
A method of administering to an individual in need thereof an enzyme replacement therapy in an injectable enzyme hydrogel formulation, wherein the injectable enzyme hydrogel formulation is not a microparticle, the method comprising:
- preparing an injectable enzyme hydrogel formulation by mixing an enzyme, a polymer, and a buffer solution to form a precursor solution;
- initiating polymerization of the precursor solution to form the injectable enzyme hydrogel formulation;
- and
- administering the enzyme hydrogel formulation to the individual in need thereof.
A method of treating Mucopolysaccharidoses (MPS) in an individual having Mucopolysaccharidoses, the method comprising:
- administering to the individual an injectable N-acetylgalactosamine 6-sulfate sulfatase (GALNS) enzyme replacement therapy, wherein the GALNS enzyme replacement therapy comprises an injectable GALNS hydrogel composition comprising GALNS, a polymer, and a buffer, wherein the enzyme hydrogel formulation is not a microparticle.
Dependencies are inferred from the claim text.