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US 2021/0198641 A1Published application
Novel mad nucleases
AssigneeInscripta, Inc.
InventorsBenjamin Mijts, Juhan Kim, Aamir Mir, Andrew Garst, Kyle Seamon
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Abstract
The present disclosure provides new RNA-guided nucleases for making rational, direct edits to nucleic acids in live cells.
Claims6
A nuclease system configured to perform nucleic acid-guided nuclease editing, wherein the nuclease system is selected from a nuclease system comprising SEQ ID NO. 8, SEQ ID NO. 32 and SEQ ID NO. 33;
- a nuclease system comprising SEQ ID NO. 8, SEQ ID NO. 34 and SEQ ID NO. 35;
- and a nuclease system comprising SEQ ID NO. 8, SEQ ID NO. 36 and SEQ ID NO. 37.
A nickase having an amino acid sequence selected from SEQ ID NOs. 51 and 52.
A dead nuclease having an amino acid sequence of SEQ ID NO. 53.
Dependencies are inferred from the claim text.