US 2021/0198516 A1 · SURFACES AND COATING COMPOSITIONS HAVING ANTIFOULING, ANTITHROMBOTIC, AND ANTIBACTERIAL PROPERTIES AND METHODS OF MAKING

Abstract

Coating compositions, coated articles including the coating compositions, and methods of making the coating compositions and coated articles are provided. In some aspects, the coating compositions are applied to a substrate having nitric oxide-releasing properties. The coating compositions can include copolymers having crosslinking agents that can be activated with mild UV light (about 345 nm to 365 nm) to avoid damaging the substrate while creating strong covalent bonds to the substrate. The copolymers can include hydrophilic repeat units, and in particular zwitterionic repeat units such as repeat units containing phosphorylcholine groups. In some aspects, the coating compositions are applied to a surface of a polymer substrate, wherein the polymer substrate had nitric oxide releasing properties. The coating compositions and the coated articles can have antifouling, antithrombotic, and/or antibacterial properties.

Claims23

Dependent claims

A coated article comprising a nitric oxide-releasing substrate having at least one surface;

and a zwitterionic polymer covalently attached to the at least one surface to form the coated article;
where the zwitterionic polymer is a random copolymer having a structure according to the following formula:
where each occurrence of Z is a zwitterionic moiety;
where, in each instance, either (i) A1 is none and A2 is ═O or (ii) A1 is a covalent bond to the at least one surface of the substrate and A2 is —OH;
where each occurrence of R1 is independently a covalent bond or a linear or branched, substituted or unsubstituted alkyl diradical having from 1 to 12 carbon atoms;
where each occurrence of R2, R3, and R4 is independently a linear or branched, substituted or unsubstituted alkyl having from 1 to 12 carbon atoms;
and
where a, b, and c are real number such that 0<a<1, 0≤b<1, 0<c<1, and a+b+c=1.

5 more elements

Dependencies are inferred from the claim text.

Surfaces and coating compositions having antifouling, antithrombotic, and antibacterial properties and methods of making

Life of this patent

Surfaces and coating compositions having antifouling, antithrombotic, and antibacterial properties and methods of making

Life of this patent

Abstract

Claims23