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US 2021/0198375 A1Published application
Fusion protein and its applicaton in preparing medicine for treating tumor and/or viral infection
AssigneeNanjing Umab-Biopharma Co., Ltd.
InventorsShifu Mo, Yong Zhao, Wei Xu, Zhichao Wang, Jie Yang, Liyun Gu, Dong Ding
Life of this patent
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Abstract
The present disclosure provides a fusion protein and methods thereof for preparing a pharmaceutical composition comprising the fusion protein and for methods for treating tumors and/or viral infections using said fusion proteins and compositions, wherein the fusion protein comprises an antibody or antigen-binding fragment thereof that specifically binds to human OX40 and a human interferon.
Claims20
A fusion protein comprising:
- a) an antibody or antigen-binding fragment thereof that specifically binds to human OX40;
- and
- b) a human interferon;
- wherein the human interferon is linked to the carboxyl- or amino-terminus of the light or heavy chain of the antibody directly or via a peptide linker.
1 more element
An antibody or antigen-binding fragment thereof that specifically binds to human OX40 comprising:
- an antibody heavy chain variable region comprising VH CDR1 having the amino acid sequence of SEQ ID NO:1, VH CDR2 having the amino acid sequence of SEQ ID NO:2, and VH CDR3 having the amino acid sequence of SEQ ID NO:3;
- and
- an antibody light chain variable region comprising VL CDR1 having the amino acid sequence of SEQ ID NO:4, VL CDR2 having the amino acid sequence of SEQ ID NO:5, and VL CDR3 having the amino acid sequence of SEQ ID NO:6.
Dependencies are inferred from the claim text.