B7-h7-binding agents and methods of use thereof
AssigneeNGM Biopharmaceuticals, Inc.
InventorsJer-Yuan Hsu, Suzanne Christine Crawley
Life of this patent
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Abstract
The present disclosure provides binding agents, such as antibodies, that specifically bind B7-H7, including human B7-H7, as well as compositions comprising the binding agents and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.
Claims99
A binding agent that specifically binds human B7-H7, which comprises:
- (a) a heavy chain variable region CDR1 comprising GYTFTEYTMH (SEQ ID NO:
- 13), a heavy chain variable region CDR2 comprising GINPNNYGAPYNQKFKG (SEQ ID NO:
- 14), and a heavy chain variable region CDR3 comprising GGYYFDY (SEQ ID NO:
- 15);
- and/or
- (b) a light chain variable region CDR1 comprising KASQDVGTAVA (SEQ ID NO:
- 16), a light chain variable region CDR2 comprising WAFTRHT (SEQ ID NO:
- 17), and a light chain variable region CDR3 comprising QQHYDTPFT (SEQ ID NO:
- 18).
A binding agent that specifically binds human B7-H7, which comprises a CDR1, CDR2, and CDR3 from a heavy chain variable region having the amino acid sequence of SEQ ID NO:
- 19 and a CDR1, CDR2, and CDR3 from a light chain variable region having the amino acid sequence of SEQ ID NO:20.
A binding agent that specifically binds human B7-H7, which comprises a CDR1, CDR2, and CDR3 from a heavy chain variable region having the amino acid sequence of SEQ ID NO:21 and a CDR1, CDR2, and CDR3 from a light chain variable region having the amino acid sequence of SEQ ID NO:22.
A binding agent that specifically binds human B7-H7, which comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:24 and a light chain comprising the amino acid sequence of SEQ ID NO:26.
A binding agent that specifically binds human B7-H7, wherein the binding agent comprises a scaffold protein and a heavy chain variable region CDR1, CDR2, and CDR3 from a heavy chain variable region comprising SEQ ID NO:
- 19 or SEQ ID NO:21 and a light chain variable region CDR1, CDR2, and CDR3 from a light chain variable region comprising SEQ ID NO:20 or SEQ ID NO:22.
A binding agent that specifically binds human B7-H7, which comprises:
- (a) a heavy chain variable region CDR1 comprising GYSFTDYIIV (SEQ ID NO:27), a heavy chain variable region CDR2 comprising KINPYYGTTTYNLRFED (SEQ ID NO:28), and a heavy chain variable region CDR3 comprising WDYVSTLFAMDY (SEQ ID NO:29);
- and
- (b) a light chain variable region CDR1 comprising KASQDVGTAVA (SEQ ID NO:
- 16), a light chain variable region CDR2 comprising WASTRHT (SEQ ID NO:30), and a light chain variable region CDR3 comprising QQYKRYYT (SEQ ID NO:31).
A binding agent that specifically binds human B7-H7, which comprises:
- (a) a heavy chain variable region CDR1 comprising GYTFTEYTMH (SEQ ID NO:
- 13), a heavy chain variable region CDR2 comprising GINPNNGGAPYNQKFKG (SEQ ID NO:34), and a heavy chain variable region CDR3 comprising GGYYFDY (SEQ ID NO:
- 15);
- and
- (b) a light chain variable region CDR1 comprising KASQDVSTAVA (SEQ ID NO:35), a light chain variable region CDR2 comprising WASTRHT (SEQ ID NO:30), and a light chain variable region CDR3 comprising QQHYDTPFT (SEQ ID NO:
- 18).
A binding agent that specifically binds human B7-H7, which comprises:
- (a) a heavy chain variable region CDR1 comprising GYTFSSYSMH (SEQ ID NO:38), a heavy chain variable region CDR2 comprising TIYPGNENTSYNQKFKG (SEQ ID NO:39), and a heavy chain variable region CDR3 comprising GGYYFDY (SEQ ID NO:
- 15);
- and
- (b) a light chain variable region CDR1 comprising KASQDVSTAVA (SEQ ID NO:35), a light chain variable region CDR2 comprising WASTRHT (SEQ ID NO:30), and a light chain variable region CDR3 comprising (QQHFDIPYW (SEQ ID NO:40).
A binding agent that specifically binds human B7-H7, which comprises:
- (a) a heavy chain variable region CDR1 comprising GYTFTTYTMH (SEQ ID NO:43), a heavy chain variable region CDR2 comprising YINPSRGYSDYSQKFQG (SEQ ID NO:44), and a heavy chain variable region CDR3 comprising GGYDFDY (SEQ ID NO:45);
- and
- (b) a light chain variable region CDR1 comprising KASQDVGTAVA (SEQ ID NO:
- 16), a light chain variable region CDR2 comprising WASTRHT (SEQ ID NO:30), and a light chain variable region CDR3 comprising QQHFITPYT (SEQ ID NO:46).
A binding agent that specifically binds human B7-H7, which comprises:
- (a) a heavy chain variable region CDR1 comprising GFSLTGYGVN (SEQ ID NO:49), a heavy chain variable region CDR2 comprising VIWGDGSTDYNSVLKS (SEQ ID NO:50), and a heavy chain variable region CDR3 comprising EATEYLYWYFDV (SEQ ID NO:51);
- and
- (b) a light chain variable region CDR1 comprising RASESVEYYGSSLMQ (SEQ ID NO:52), a light chain variable region CDR2 comprising AASNVES (SEQ ID NO:53), and a light chain variable region CDR3 comprising QQGRRVPWT (SEQ ID NO:54).
A binding agent that specifically binds human B7-H7, which comprises:
- (a) a heavy chain variable region CDR1 comprising GYSFTGYNMN (SEQ ID NO:57), a heavy chain variable region CDR2 comprising NIDPYSGGSTYNQKFKG (SEQ ID NO:58), and a heavy chain variable region CDR3 comprising SVYDAPWLAH (SEQ ID NO:59);
- and
- (b) a light chain variable region CDR1 comprising RASENIYIYLA (SEQ ID NO:60), a light chain variable region CDR2 comprising NAKTLAE (SEQ ID NO:61), and a light chain variable region CDR3 comprising QHHYGTPPT (SEQ ID NO:62).
A binding agent that specifically binds human B7-H7, which comprises:
- (a) a heavy chain variable region CDR1 comprising GYSFTGYNMN (SEQ ID NO:57), a heavy chain variable region CDR2 comprising NIDPYSGGSTYNQKFKG (SEQ ID NO:58), and a heavy chain variable region CDR3 comprising SFYDAPYLTY (SEQ ID NO:65);
- and
- (b) a light chain variable region CDR1 comprising RASENIFIYLA (SEQ ID NO:66), a light chain variable region CDR2 comprising NAKTLAE (SEQ ID NO:61), and a light chain variable region CDR3 comprising QHHYGTPPT (SEQ ID NO:62).
A binding agent that specifically binds human B7-H7, which comprises:
- (a) a heavy chain variable region CDR1 comprising GYTFTSFWIH (SEQ ID NO:69), a heavy chain variable region CDR2 comprising YIIPNTDYTEYNQKFKD (SEQ ID NO:70), and a heavy chain variable region CDR3 comprising GLRGAYYFDY (SEQ ID NO:71);
- and
- (b) a light chain variable region CDR1 comprising RSSQSVSTSTNGYMH (SEQ ID NO:72), a light chain variable region CDR2 comprising YASNLES (SEQ ID NO:73), and a light chain variable region CDR3 comprising QHSWVLPYT (SEQ ID NO:74).
Dependencies are inferred from the claim text.