Thioamide-modified peptides and uses thereof
AssigneesThe Trustees of the University of Pennsylvania, President and Fellows of Harvard College
InventorsE. James PETERSSON, Alan SAGHATELIAN
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Abstract
The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
Claims25
A peptide, or a salt or solvate thereof, comprising at least one selected from the group consisting of SEQ ID NOs:
- 11-18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48 and 50-51, wherein the C-terminus of the peptide is optionally amide protected.
6-10. (canceled)
A method of treating or preventing diabetes or obesity in a subject in need thereof, wherein the method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a thioamide-modified peptide.
A method of treating or preventing a cardiac disease or disorder in a subject in need thereof, wherein the method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a thioamide-modified peptide.
A kit comprising a thioamide-modified peptide, and an instructional material for use thereof, wherein the instructional material comprises instructions for treating or preventing a disease or disorder in a subject using the thioamide-modified peptide.
Dependencies are inferred from the claim text.