Epstein-barr virus antigen constructs
AssigneeGlaxosmithkline Biologicals SA
InventorsStefania CAPONE, Antonella FOLGORI, Armin LAHM, Benjamin WIZEL
Life of this patent
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Abstract
The invention provides Epstein-Barr Virus antigen polynucleotides, polypeptides and vectors; as well as immunogenic compositions comprising the same. It includes the use of Epstein-Barr Virus antigen constructs to produce vaccines for treating and preventing Epstein-Barr Virus infections and Epstein-Barr Virus-associated diseases, such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus.
Claims15
1-44. (canceled)
A polynucleotide encoding a polypeptide comprising:
- (a) at least one fragment of at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80 at least 90 or at least 100 amino acids of SEQ ID NO:
- 1,
- (b) at least one fragment of at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80 at least 90 or at least 100 amino acids of SEQ ID NO:
- 6,
- (c) at least one fragment of at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80 at least 90 or at least 100 amino acids of SEQ ID NO:
- 11, and
- (d) at least one fragment of at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80 at least 90 or at least 100 amino acids of SEQ ID NO:
- 13;
- wherein the polynucleotide is operatively linked to one or more sequences which direct expression of said polypeptide in a host cell.
The polynucleotide of claim 1, wherein the polypeptide further comprises at least one fragment of at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80 at least 90 or at least 100 amino acids of SEQ ID NO:
- 21.
Dependencies are inferred from the claim text.