Cell-penetrating compstatin analogs and uses thereof
AssigneeApellis Pharmaceuticals, Inc.
InventorsCedric Francois, Pascal Deschatelets, Monica Gerber
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Abstract
In some aspects, the present invention cell-penetrating compstatin analog and compositions comprising cell-penetrating compstatin analog. In some aspects, the invention further provides methods of using cell-penetrating compstatin analogs treat a complement-mediated disorder, e.g., to inhibit complement-mediated damage to a cell, tissue, or organ, to inhibit production or release of biologically active C3 cleavage products.
Claims32
A compound comprising a compstatin analog moiety and a cell penetrating moiety (CPM).
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A composition comprising (a) an isolated cell, tissue, or organ;
- and (b) a cell penetrating compstatin analog.
A method of characterizing a cell-penetrating compstatin analog (CPCA), the method comprising:
- (a) contacting a cell that expresses primate C3 with a CPCA in vitro;
- and (b) assessing the activity of the CPCA.
Dependencies are inferred from the claim text.