Method of producing imidazole dipeptides

Abstract

It is an objective of the present invention to provide a method of producing imidazole dipeptides that reduces burden and time for an elution treatment when compared to the prior arts, and furthermore, that can produce high purity imidazole dipeptides with less contamination of creatinine. The above objective is achieved by a method of producing high purity imidazole dipeptides, comprising: (1) subjecting an animal extract containing imidazole dipeptides and creatinine to an ion adsorption treatment in which the animal extract is brought into contact with a strongly acidic cation exchange resin having an alkali metal salt type of ion exchange group at a predetermined pH value to adsorb the imidazole dipeptides onto the resin; and (2) subjecting the strongly acidic cation exchange resin adsorbing the imidazole dipeptides to an elution treatment with the use of an aqueous alkaline solution and at a predetermined pH value to obtain high purity imidazole dipeptides.

Dependencies are inferred from the claim text.