Bifunctional compounds for degrading btk via ubiquitin proteosome pathway

The method of any of the previous claims, wherein the bifunctional compound is a compound of Formula (A)

• or a pharmaceutically acceptable salt thereof, wherein
• W is CH or N;
• D is a bond or —NH—;
• Ring A is phenyl, a 9-10 membered bicyclic aryl, a 5-6 membered partially or fully unsaturated monocyclic heterocycle, or a 9-10 membered bicyclic heteroaryl, wherein the monocyclic heterocycle and bicyclic heteroaryl of Ring A each possess one to three heteroatoms independently selected from N, O, or S, wherein Ring A is optionally and independently substituted with up to three substituents selected from halo, —CN, —COOH, NH2, and optionally substituted C10.6 alkyl;
• Ring B is a phenyl, a 5-6 membered heteroaryl, a 4-6 membered heterocycloalkyl, or a 8-10 membered spiro bicyclic heterocycle, wherein Ring B is optionally substituted, and wherein the heteroaryl and heterocycloalkyl of Ring B has one to three heteroatoms independently selected from N, O, or S;
• L is —X1—X2—X3—X4—X5—;
• X1 is a bond, —C(O)—N(R)—, —N(R)—C(O)—, —(O—CH2—CH2)m—, —O(C6H4)—, —(O—CH2—CH2—CH2)m—, —C1-5 alkyl-, 7-12 membered spiro or fused bicyclic heterocycloalkyl having one to three heteroatoms independently selected from N, O, or S, or 4-6 membered monocyclic heterocycloalkyl having one to two heteroatoms independently selected from N, O, or S, wherein each of the monocyclic and bicyclic heterocycloalkyl of X1 is optionally substituted with —CH3;
• X2 is a bond, —(O—CH2—CH2)n—, —(CH2—CH2—O)n—, —N(R)—C(O)—, —N(R)—, —C(O)—, —C1-5 alkyl-, 4-6 membered monocyclic cycloalkyl, or 4-6 membered monocyclic heterocycloalkyl having one to two heteroatoms independently selected from N, O, or S;
• X3 is a bond, —C10.8 alkyl-, —C≡C—, 4-6 membered cycloalkyl, —N(R)—, —N(R)—C(O)—, —(O—CH2—CH2)p—, —(CH2—CH2—O)p—, 4-6 membered heterocycloalkyl having one to two heteroatoms independently selected from N, O, or S, wherein the heterocycloalkyl is optionally substituted with —CH3;
• X4 is a bond, —CH2—CH2—N(R)—, —N(R)—, —C1-4 alkyl-, —(O—CH2—CH2—CH2)m—, a 5-6 membered saturated, partially unsaturated, or fully unsaturated carbocycle, or a 5-6 membered saturated, partially unsaturated, or fully unsaturated heterocycle having one to three heteroatoms independently selected from N, O, or S;
• X5 is a bond, —C1-4 alkyl-, —N(R)—, —O—, —C(O)—, or —C(O)—N(R)—;
• each R is independently hydrogen or —C1-3 alkyl;
• and
• each of m, n, and p is independently an integer from one to three;
• and
• Y is
• wherein
• each R2 is independently halo, —CN, or C1-4 alkyl, wherein each C1-4 alkyl is optionally and independently substituted with up to three instances of halo, —CN, —COOH, —COONH2, —NH2, or —CF3;
• each R″ and R′″ are independently hydrogen or, together with the atoms to which they are attached, form a 5-6 membered partially unsaturated or fully unsaturated benzofuzed heterocycle;
• each Z is —C(RA)2— or —C(O)—;
• each RA is independently hydrogen or —C1-4 alkyl;
• and
• q is zero, one, or two.