Fused bicyclic compounds useful as ubiquitin-specific peptidase 30 inhibitors

A compound of Formula (I′):

• or a pharmaceutically acceptable salt thereof, wherein:
• V is selected from a bond, C(O), and CRfRg;
• X is selected from N and CRx;
• Y is selected from a bond, C(O), and CRjRk;
• Z is selected from C(O) and CRjRk;
• L is —(CH2)n—;
• n is 0, 1, 2, or 3,
• wherein each methylene unit of L is optionally substituted with one or two C1-C6 alkyl, and
• wherein if n is 2 or 3, then one methylene unit of L is optionally replaced with a heteroatom selected from nitrogen, oxygen, and sulfur;
• each occurrence of Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rj, Rk, and Rx is independently selected from hydrogen, halogen, —OR, —NR2, —CN, —SR, optionally substituted C1-C6 aliphatic, optionally substituted C3-C6 cycloalkyl, or optionally substituted 3- to 6-membered heterocyclyl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur;
• or Rb and Rc, or Rd and Re, or Rf and Rg, or Rh and Ri, or Rj and Rk, or a combination thereof, combine with the carbon to which they are attached to form an optionally substituted C3-C6 cycloalkyl or an optionally substituted 3- to 6-membered heterocyclyl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur;
• wherein an optionally substituted Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rj, Rk, and Rx group may be substituted with one or more R1;
• Ring A is selected from C3-C13 cycloalkyl, 3- to 13-membered heterocyclyl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur, phenyl, C10 aryl, and 5- to 10-membered heteroaryl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur,
• wherein Ring A is optionally substituted with one or more W;
• each W is independently selected from halogen, oxo, —OR, —OC(O)R′, —NR2, —NRC(O)R′, —NRS(O)2R′, —CN, —NO2, —SR, —C(O)OR, —C(O)NR2, —S(O)2R′, —S(O)2NR2, optionally substituted C1-C6 aliphatic, optionally substituted C3-C10 cycloalkyl, optionally substituted 3- to 10-membered heterocyclyl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur, optionally substituted phenyl, optionally substituted C10 aryl, and optionally substituted 5- to 10-membered heteroaryl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur,
• wherein an optionally substituted W group may be substituted with one or more R1;
• each R1 is independently selected from oxo, halogen, —OR, —OC(O)R′, —NR2, —NRC(O)R′, —NRS(O)2R′, —CN, —NO2, —SR, —C(O)OR, —C(O)NR2, —S(O)2R′, —S(O)2NR2, C1-C6 aliphatic, C1-C6 haloaliphatic, —(CH2)m(C3-C10cycloalkyl), —(CH2)m(3- to 10-membered heterocyclyl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur), —(CH2)m(phenyl), —(CH2)m(C10aryl), and —(CH2)m(5- to 10-membered heteroaryl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur);
• each R is independently selected from hydrogen, C1-C6 aliphatic, C1-C6 haloaliphatic, C3-C6 cycloalkyl, 3- to 6-membered heterocyclyl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur, phenyl, and 5- to 6-membered heteroaryl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur;
• each R′ is independently selected from C1-C6 aliphatic, C1-C6 haloaliphatic, C3-C6 cycloalkyl, 3- to 6-membered heterocyclyl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur, phenyl, and 5- to 6-membered heteroaryl containing 1 to 3 heteroatoms selected from nitrogen, oxygen, and sulfur;
• and
• each m is independently 0, 1, or 2.