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US 2021/0198262 A1Published application
Method of preparation of florasulam
AssigneeDow AgroSciences LLC
InventorsJossian Oppenheimer, Michael Gullo, David E. Podhorez, Justin A. Alberts
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Abstract
The present disclosure concerns a method for preparing florasulam which involves treating a solution of 2,6-difluoroaniline in 1,2-propylene glycol with: a) sulfonyl chloride III and then b) a base to provide, after workup and isolation, florasulam (I) in yields of about 65-85%. The treatment of 2,6-difluoroaniline with sulfonyl chloride III and the base are conducted by controlled additions.
Claims21
A method of preparing florasulam (compound I)
- comprising:
- a) adding sulfonyl chloride III
- to 2,6-difluoroaniline to form a mixture;
- and
- b) adding a base to the mixture formed in step a).
2 more elements
2-12. (canceled)
A method of preparing florasulam (compound I)
- comprising:
- a) controlled adding of sulfonyl chloride III
- to 2,6-difluoroaniline to form a mixture;
- and
- b) controlled adding of a base to the mixture formed in step a).
2 more elements
A method of preparing florasulam (compound I)
- comprising:
- a) adding sulfonyl chloride III
- to 2,6-difluoroaniline while maintaining a temperature during the adding of 20-30° C. to form a mixture;
- and
- b) adding a base to the mixture formed in step a) while maintaining the temperature during the adding of 20-30° C.
2 more elements
Dependencies are inferred from the claim text.