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US 2021/0197181 A1Published application
Kits comprising containers with at least one solid catalytically active compound, and their uses in solid state reaction
AssigneeRD&C Research, Development & Consulting GmbH
InventorsNorbert HANDLER, Helmut BUSCHMANN
Life of this patent
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Abstract
Subject matter of the present invention are kits comprising containers with at least one solid catalytically active compound, their uses in processes for simulating and predicting the transformation of a compound that is preferably a solid active pharmaceutical ingredient (API), preferably an API in combination with an excipient, in a shortened time span, into the respective degradation product(s).
Claims20
Kit comprising the following components:
- Container comprising a catalyst that is 3-15% (w/w) sulfuric acid or chlorosulfonic acid absorbed on silica gel 60 (70-230 mesh), preferably 3-10% (w/w) sulfuric acid or chlorosulfonic acid absorbed on silica gel, more preferably about 5% (w/w) sulfuric acid or chlorosulfonic acid on silica gel, and/or
- Container comprising a catalyst that is 3-15% (w/w) KOH or NaOH absorbed on silica gel or alox, preferably 3-10% (w/w) KOH or NaOH absorbed on silica gel or alox, more preferably about 5% (w/w) KOH or NaOH on silica gel or alox, and
- Container comprising a catalyst that is 3-15% (w/w) KMnO4 absorbed on silica gel or alox, preferably 3-10% (w/w) KMnO4 absorbed on silica gel or alox, more preferably about 5% (w/w) KMnO4 on silica gel or alox, and
- Optionally a container comprising a neutral catalyst that is pure silica gel 60 (70-230 mesh) or that is pure alox.
1 more element
Dependencies are inferred from the claim text.