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US 2021/0196841 A1Published application
Methods of Imaging and Delivering Therapeutic Agents
AssigneeDrexel University
InventorsSteven WRENN, Brett ANGEL, Andrew KOHUT, Aaron FAFARMAN, Michael CIMORELLI
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Abstract
The present disclosure provides imaging agents that are useful for the detection and evaluation of heart conditions, such as myocardial infarction. Upon activation, the imaging agents of the present disclosure may be detected using an ultrasound imaging device.
Claims30
A method for imaging a portion of a subject's body, the method comprising:
- (a) administering to the subject an imaging agent, wherein the imaging agent comprises:
- (1) a liquid core, comprising insoluble liquid droplets dispersed in an inner core liquid;
- (2) a nesting shell surrounding the liquid core, comprising a phospholipid or a polymer,
- wherein the nesting shell is more permeable to the inner core liquid in the presence of an electric field than in the absence of an electric field;
- and
- (b) applying ultrasound to the portion of the subject's body.
3 more elements
A method for imaging a portion of a subject's heart, the method comprising:
- (a) administering to the subject an imaging agent, wherein the imaging agent comprises:
- (1) a liquid core, comprising insoluble liquid droplets dispersed in an inner core liquid;
- (2) a bilayer nesting shell surrounding the liquid core, the bilayer nesting shell comprising a phospholipid;
- wherein the nesting shell is more permeable to the inner core liquid in depolarizing heart tissue and
- (b) applying ultrasound to the subject's heart.
2 more elements
A method for delivering a therapeutic agent to a portion of a subject's body, the method comprising:
- (a) administering to the subject a payload delivery agent, wherein the payload delivery agent comprises:
- (1) a liquid core comprising insoluble liquid droplets dispersed in an inner core liquid;
- (2) a nesting shell surrounding the liquid core, comprising a phospholipid or a polymer;
- and
- (3) a therapeutic agent;
- and
- wherein the nesting shell is more permeable to the inner core liquid in the presence of an electric field than in the absence of an electric field.
4 more elements
Dependencies are inferred from the claim text.