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US 2021/0196840 A1Published application
Gadolinium bearing pcta-based contrast agents
AssigneeBracco Imaging S.P.A.
InventorsRoberta NAPOLITANO, Luciano LATTUADA, Zsolt BARANYAI, Nicole GUIDOLIN, Giuseppe MARAZZI
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Abstract
The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
Claims16
1-21. (canceled)
A Gd(PCTA-tris-glutaric acid) complex of formula
- or a pharmaceutically acceptable salt thereof, wherein at least 50% of the complex consists of the enantiomer [(αR,α′R,α″R)-α,α′,α″-tris(2-carboxyethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetato(3-)-κN3,κN6,κN9,κN15,κO3,κO6,κO9]-gadolinium having the formula Ia (enantiomer RRR)
- the enantiomer [(αS,α′S,α″S)-α,α′,α″-tris(2-carboxyethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetato(3-)-κN3,κN6,κN9,κN15,κO3,κO6,κO9]-gadolinium having the formula Ib (enantiomer SSS)
- or a mixture of the RRR and SSS enantiomers.
Dependencies are inferred from the claim text.