Anti-cd37 immunoconjugate dosing regimens

A method for treating a cancer in a human patient comprising administering to the patient a pharmaceutical composition comprising an anti-CD37 immunoconjugate once a week in a three-week cycle, wherein:

• a) 0.4 mg/kg of the immunoconjugate are administered in the first week, 0.2 mg/kg are administered in the second week, and 0.2 mg/kg are administered in the third week;
• b) 0.2 mg/kg of the immunoconjugate are administered in the first week, 0.2 mg/kg are administered in the second week, and 0.2 mg/kg are administered in the third week;
• c) 0.3 mg/kg of the immunoconjugate are administered in the first week, 0.3 mg/kg are administered in the second week, and 0.3 mg/kg are administered in the third week;
• d) 0.3 mg/kg of the immunoconjugate are administered in the first week, 0.3 mg/kg are administered in the second week, and 0.2 mg/kg are administered in the third week;
• e) 0.3 mg/kg of the immunoconjugate are administered in the first week, 0.2 mg/kg are administered in the second week, and 0.2 mg/kg are administered in the third week;
• f) 0.4 mg/kg of the immunoconjugate are administered in the first week, 0.3 mg/kg are administered in the second week, and 0.3 mg/kg are administered in the third week;
• g) 0.4 mg/kg of the immunoconjugate are administered in the first week, 0.3 mg/kg are administered in the second week, and 0.2 mg/kg are administered in the third week;
• h) 0.5 mg/kg of the immunoconjugate are administered in the first week, 0.3 mg/kg is administered in the second week, and 0.2 mg/kg are administered in the third week;
• i) 0.5 mg/kg of the immunoconjugate are administered in the first week, 0.2 mg/kg are administered in the second week, and 0.2 mg/kg are administered in the third week;
• or
• j) 0.6 mg/kg of the immunoconjugate are administered in the first week, 0.2 mg/kg are administered in the second week, and 0.2 mg/kg are administered in the third week;
• wherein the immunoconjugate comprises (i) an antibody or antigen-binding fragment thereof comprising a VH-CDR1 comprising the amino acid sequence of SEQ ID NO:2, a VH-CDR2 comprising the amino acid sequence of SEQ ID NO:3, a VH-CDR3 comprising the amino acid sequence of SEQ ID NO:4, a VL-CDR1 comprising the amino acid sequence of SEQ ID NO:5, a VL-CDR2 comprising the amino acid sequence of SEQ ID NO:6, and a VL-CDR3 comprising the amino acid sequence of SEQ ID NO:7 and (ii) a maytansinoid.