Glypisome as an enhancer of angiogenic growth factor activity
AssigneeBoard of Regents, The University of Texas System
InventorsAaron Baker, Anthony Monteforte
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Abstract
Disclosed herein are proteovesicles, referred to herein as a “glypisomes”, that comprise a recombinant glypican polypeptide embedded in a lipid vesicle. Also disclosed is the use of these glypisomes to enhance the activity of growth factors.
Claims20
-15. (canceled)
A method for enhancing the angiogenic or wound healing activity of a growth factor in a subject, comprising administering to a subject in need thereof a composition comprising, a biodegradable microcapsule or microbead encapsulating therein effective amounts of a growth factor and a proteovesicle comprising a recombinant glypican polypeptide embedded in a lipid vesicle;
- wherein the microcapsule or microbead comprises a biocompatible hydrogel;
- and wherein the lipid vesicle is prepared through the self-association of the glypican polypeptide.
A method for promoting angiogenesis in a subject, comprising administering to a subject in need thereof a composition comprising, a biodegradable microcapsule or microbead encapsulating therein effective amounts of a growth factor and a proteovesicle comprising a recombinant glypican polypeptide embedded in a lipid vesicle;
- wherein the microcapsule or microbead comprises a biocompatible hydrogel;
- and wherein the lipid vesicle is prepared through the self-association of the glypican polypeptide.
A method for promoting nerve regeneration in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising, a biodegradable microcapsule or microbead encapsulating therein effective amounts of a growth factor and a proteovesicle comprising a recombinant glypican polypeptide embedded in a lipid vesicle;
- wherein the microcapsule or microbead comprises a biocompatible hydrogel;
- and wherein the lipid vesicle is prepared through the self-association of the glypican polypeptide.
Dependencies are inferred from the claim text.