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AssigneeYale University
InventorsYungChi Cheng, Wing Lam, Zaoli Jiang
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The invention relates in one aspect to the unexpected discovery that herbal extracts of the Rubia cordifolia plant are potent inhibitors of a range of receptors, proteins and enzymes implicated in the pathology of a number of common diseases and disorders. In certain embodiments, the method is useful for treating at least one disease or disorder related to a steroid hormone receptor including prostate cancer, breast cancer, ovarian cancer, lung cancer, leukemia and lymphoma. In other embodiments, the method is useful for treating at least one disease or disorder related to the expression of at least one protein selected from the group consisting of Brd4, Brd2, cyclin D1, p53, Gata3 and CD47.
A method of treating at least one disease or disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an herbal extract of Rubia cordifolia or a fraction thereof, or any active chemical species present in the herbal extract or the fraction thereof, wherein the disease or disorder is related to the activity of at least one steroid hormone receptor or the expression of at least one protein selected from the group consisting of Brd4, Brd2, cyclin D1, p53, Gata3, Poly[ADP-ribose] polymerase-1 (PARP-1) and CD47.
Dependencies are inferred from the claim text.