Drug Targets of Delayed Aging and Human Brain Diseases
AssigneeTexas Tech University System
InventorsHemachandra Reddy, Chandra Sekhar Kurova
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Abstract
The present invention includes a molecule and method of identifying and a method of using the molecule to inhibit the interaction of Aβ and Drp1 proteins, including diethyl(3,4-dihydroxyphenethylamine)(quinolin-4-yl)methylphosphonate (DDQ); phosphonium,[10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenyl-, methanesulfonate) (MitoQ); (3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide (Dynasore); and/or (3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, or derivatives thereof.
Claims20
A molecule selected from phosphonium cationic molecules;
- quinoline alpha aminophosphonates;
- napthaline alpha aminophosphonates, or hexahydropyramidine carboxylates, that inhibit the interaction of Aβ and Drp1 proteins in an amount effective to inhibit the interaction of Aβ and Drp1 proteins in nerve cells.
A method for identifying a molecule that inhibits the interaction of Aβ and Drp1 proteins comprising:
- obtaining a database of molecular coordinates for the regions of the Aβ and Drp1 proteins that interact;
- obtaining a database of molecules comprising molecular coordinates, wherein the molecule is selected from at least one of:
- phosphonium cation based structures;
- quinoline based alpha aminophosphonates;
- napthaline based alpha aminophosphonates, or hexahydropyramidine carboxylates structures;
- identifying the molecules from the database of molecules that fit between the regions in which the Aβ and Drp1 proteins that interact;
- and
- testing in vitro the ability of the one or more molecules that fit between the regions in which the Aβ and Drp1 proteins to prevent binding of Aβ and Drp1 proteins.
A method of treating a neuropathy caused by the interaction of Aβ and Drp1 proteins comprising providing a molecule in an amount that is effective to inhibit the interaction of the Aβ and Drp1 proteins in nerve cells in a subject in need thereof, wherein the molecule is selected from at least one of:
- phosphonium cation-based structures;
- quinoline based alpha aminophosphonates;
- napthaline based alpha aminophosphonates, or hexahydropyramidine carboxylates structures.
Dependencies are inferred from the claim text.