Isoxazoline parasiticide formulations and methods for treating blepharitis
AssigneeTarsus Pharmaceuticals, Inc.
InventorsBobak Robert Azamian, Douglas Michael Ackermann, Shawn D. Hickok, Joseph G. Vehige
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods for treating or preventing ophthalmic and dermatologic conditions in a patient, including ocular surface conditions such as blepharitis. The methods can include topically administering directly to an ocular surface of one or more eyes of a patient in need of treatment thereof an effective amount of an isoxazoline parasiticide, formamidine parasiticide, or other active ingredient, formulated into an ophthalmic composition, the ophthalmic composition further comprising a pharmaceutically acceptable vehicle. Compositions are also disclosed.
Claims25
A method for treating Demodex blepharitis, comprising:
- topically administering directly to an ocular surface of one or more eyes of a human patient in need of treatment thereof an effective amount of an isoxazoline parasiticide, formulated into an ophthalmic composition, the ophthalmic composition further comprising a pharmaceutically acceptable vehicle,
- wherein the ophthalmic composition comprises an eye drop,
- wherein the isoxazoline parasiticide is the sole active ingredient of the ophthalmic composition,
- wherein the isoxazoline parasiticide comprises lotilaner.
A method for treating Demodex blepharitis, comprising:
- topically administering directly to one or more of the eye, eyelids, or eyelashes of a human patient in need of treatment thereof an effective amount of an isoxazoline parasiticide, formulated into an ophthalmic composition further comprising a pharmaceutically acceptable vehicle,
- wherein the ophthalmic composition comprises an eye drop, and
- wherein the isoxazoline parasiticide comprises lotilaner.
A method for treating an ocular Demodex infestation, comprising:
- topically administering directly to an ocular surface of one or more eyes of a human patient in need of treatment thereof, an effective amount of an isoxazoline parasiticide, formulated into an ophthalmic composition further comprising a pharmaceutically acceptable vehicle,
- wherein the ophthalmic composition is sterile,
- wherein the ophthalmic composition comprises an eye drop,
- wherein the ophthalmic composition does not comprise tea tree oil, and
- wherein the isoxazoline parasiticide comprises lotilaner,
- wherein topically administering occurs twice daily for at least 4 weeks.
A method for treating an ocular Demodex infestation, comprising:
- topically administering to an ocular surface of one or more eyes of a human patient in need of treatment thereof, an effective amount of an isoxazoline parasiticide, formulated into an ophthalmic composition further comprising a pharmaceutically acceptable vehicle,
- wherein the ophthalmic composition comprises an eye drop, and
- wherein the isoxazoline parasiticide comprises lotilaner.
Dependencies are inferred from the claim text.