6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use

A method for treating a patient having a disease mediated by a USP7 malfunction comprising the step of administering a therapeutically effective amount of one or more compounds having a formula

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is hydrogen, an alkyl or an acyl;
• R2 is a heterocyclyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl, heteroaryl, arylalkyl, arylalkenyl, or arylalkynyl, each of which is optionally substituted;
• R3, R4, R6, and R7 represent five substituents each independently selected from the group consisting of hydrogen, halo, azido, cyano, nitro, hydroxy, amino, thio, and derivatives thereof, and an acyl, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, oxyalkyl, heteroalkynyl, a heterocyclyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl, arylalkyl, arylalkenyl, and arylalkynyl, each of which is optionally substituted;
• or any two adjacent substituents that are taken together with the attached carbons to form an optionally substituted heterocycle and each of other substituents is defined as above;
• one or more of R3, R4, R6, and R7 are not hydrogen;
• R5 is —OR, wherein R is an alkyl;
• and
• R8 is cyano or a carboxy ester,
• and one or more carriers, diluents, or excipients, to a patient in need of relief from said disorder.