Pharmaceutical combination and composition, and combination preparation containing glucokinase activator and biguanide hypoglycemic drug as well as preparation method and use thereof
AssigneeHua Medicine (Shanghai) Ltd.
InventorsLi Chen, Yongguo Li, Gaosen Wang
Life of this patent
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Abstract
A pharmaceutical combination. The pharmaceutical combination contains a glucokinase activator or a pharmaceutically acceptable salt thereof, an isotopic marker thereof, a crystalline form thereof, a hydrate, a solvate, a diastereoisomer or an enantiomer form, and a biguanide hypoglycemic drug. A pharmaceutical composition and a fixed dose combination preparation as well as a preparation method and use of the pharmaceutical composition and the fixed dose combination preparation.
Claims63
A pharmaceutical combination, comprising:
- (a) a glucokinase activator, wherein the glucokinase activator is a compound represented by the following formulae, or a pharmaceutically acceptable salt, an isotope labeled analogue, a crystalline form, a hydrate, a solvate, or a diastereomeric or enantiomeric form thereof,
- (b) a biguanide hypoglycemic drug;
- wherein the above-mentioned drugs (a) and (b) are used simultaneously, separately or sequentially.
A fixed dose combination formulation, comprising:
- (a) a glucokinase activator, which is a compound represented by the following formulae, or a pharmaceutically acceptable salt, an isotope labeled analogue, a crystalline form, a hydrate, a solvate, or a diastereomeric or enantiomeric form thereof,
- (b) a biguanide hypoglycemic drug;
- and
- (c) one or more excipients.
A method for preparing the fixed dose combination formulation of any one of the preceding claims, comprising incorporating the active ingredients into one or more excipients for granulation, preferably further filling the obtained granule mixture into a vial, a sachet or a capsule, or compressing it into a tablet with a desired shape;
- and more preferably, further coating the obtained tablet.
Dependencies are inferred from the claim text.