Pharmaceutical combination, composition and compound preparation comprising glucokinase activator and dpp-iv inhibitor, and preparation method and use thereof
AssigneeHua Medicine (Shanghai) Ltd.
InventorsLi Chen, Yongguo Li, Gaosen Wang, Huisheng Gao
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Abstract
Disclosed is a pharmaceutical combination comprising a glucokinase activator or a pharmaceutically acceptable salt thereof, an isotopic label thereof, a crystalline form thereof, a hydrate, a solvate, a diastereomeric or enantiomeric form thereof, and a DPP-IV inhibitor. Disclosed are a pharmaceutical composition and a fixed dose of a compound preparation, and the methods for preparing the pharmaceutical composition and the fixed dose of the compound preparation and the uses thereof.
Claims77
A pharmaceutical combination, comprising:
- (a) a glucokinase activator, wherein the glucokinase activator is a compound represented by the following formulae, or a pharmaceutically acceptable salt, an isotope labeled analogue, a crystalline form, a hydrate, a solvate, a diastereomeric or enantiomeric form thereof,
- (b) a DPP-IV inhibitor;
- wherein the above-mentioned drugs (a) and (b) are used simultaneously, separately or sequentially.
A fixed dose combination formulation, comprising:
- (a) a glucokinase activator, which is a compound represented by the following formulae, or a pharmaceutically acceptable salt, an isotope labeled analogue, a crystalline form, a hydrate, a solvate, a diastereomeric or enantiomeric form thereof,
- (b) a DPP-IV inhibitor;
- and
- (c) one or more excipients.
A method for preparing the fixed dose combination formulation of any one of the preceding claims, comprising incorporating the active ingredients into one or more excipients for granulation, preferably further filling the obtained granule mixture into a vial, a sachet or a capsule, or compressing it into a tablet with a desired shape;
- more preferably, further coating the obtained tablet.
Dependencies are inferred from the claim text.