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US 2021/0196679 A1Published application
Materials and methods for improving gastrointestinal function
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsSadasivan VIDYASAGAR, Paul OKUNIEFF, Lurong ZHANG
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Abstract
The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity.
Claims22
A method for promoting intestinal health in a subject in need thereof, the method comprising:
- administering a formulation comprising free amino acids to the subject in need thereof:
- wherein the formulation is administered via enteral administration;
- and
- wherein the free amino acids comprise, as free amino acids, a therapeutically effective amount of serine and valine;
- and
- a therapeutically effective amount of at least one additional free amino acid of threonine, lysine, glycine, aspartic acid, isoleucine, tryptophan, or tyrosine, or any combination thereof;
- wherein the therapeutically effective amount of the serine and valine and the therapeutically effective amount of the at least one additional free amino acid promotes intestinal health in the subject;
- wherein the formulation does not comprise glucose, or when the formulation does comprise glucose, the glucose is present in a concentration equal to or less than 10 mM;
- wherein the formulation does not comprise:
- free amino acid glutamine;
- a glutamine-containing dipeptide;
- or any combination thereof;
- wherein the formulation does not comprise riboflavin;
- and
- wherein a therapeutically effective amount of the formulation promotes intestinal health in the subject.
12 more elements
Dependencies are inferred from the claim text.