Compositions and methods for treating and preventing respiratory viral infections using green tree extract
AssigneeAugusta University Research Institute, Inc.
InventorStephen D. Hsu
Life of this patent
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Abstract
Modified green tea polyphenol compositions and their methods of use in treating and preventing SARS-CoV-2 infections are provided. An exemplary green tea polyphenol composition includes (−)-epigallocatechin-3-gallate that can be esterified with a C1-C30 group in at least one position and a carrier such as glycerol. The modified green tea polyphenol compositions can be used to treat and prevent SARS-CoV-2 infections without coming into contact with the viral cell.
Claims27
A method for inhibiting or reducing respiratory viral infection in a subject comprising:
- administering to the subject an effective amount of a composition comprising at least one green tea polyphenol esterified with a C1-C30 group in at least one position and a carrier to inhibit or reduce entry of SARS-CoV-2 into respiratory epithelial cells of the subject.
A method of reducing the risk of a viral infection in a subject comprising administering to the subject an effective amount of a prophylactic composition comprising (−)-epigallocatechin-3-gallate-palmitate and glycerol to inhibit or reduce viral infection in respiratory epithelial cells of the subject.
A method for preventing the replication of respiratory viral infection in a subject comprising:
- administering to the subject an effective amount of a composition comprising at least one green tea polyphenol esterified with a C1-C30 group in at least one position and a carrier to prevent entry of SARS-CoV-2 into respiratory epithelial cells of the subject.
A composition comprising:
- a prophylactically effective amount of epigallocatechin-3-gallate-palmitate and glycerol to inhibit or reduce viral entry into respiratory epithelial cells of a subject, wherein the composition is formulated for nasal, bronchial, or pulmonary administration.
Dependencies are inferred from the claim text.