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US 2021/0196650 A1Published application
Systems comprising a composite backing and methods for long term transdermal administration
AssigneeCorium, Inc.
InventorsEun Soo Lee, Amit K. Jain, Parminder Singh
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Abstract
Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.
Claims21
A method for treating Alzheimer's disease, comprising:
- providing a transdermal patch comprised of
- a composite backing layer comprised of (i) a first layer comprised of a polymer fabric or a polymer film having a stretchability of at least 5% in at least one direction;
- (ii) a second layer comprised of one or more adhesive polymers;
- and (iii) a third layer comprised of one or more polymer films;
- wherein the first and second layers are in contact and the second and third layers are in contact, and wherein the third layer comprises cuts formed at least partially through the layer;
- and
- an adhesive matrix drug layer laminated to the third layer, the adhesive matrix drug layer comprising a drug.
4 more elements
A method for delivery of donepezil through skin, comprising:
- providing a transdermal patch comprised of a composite backing layer comprising (i) a first layer comprised of a polymer fabric or a polymer film having a stretchability of at least 5% in at least one direction;
- (ii) a second layer comprised one or more adhesive polymers;
- and (iii) a third layer comprised of one or more polymer films, wherein the third layer comprises cuts formed at least partially through the layer;
- wherein the first layer, second layer, and third layers are arranged in contact as a composite;
- (iv) an adhesive drug layer comprising donepezil, the adhesive drug layer laminated to the third layer;
- and (v) a release liner;
- wherein donepezil is delivered through skin upon removal of the release liner;
- and application of the transdermal patch to skin.
5 more elements
A method for treating Alzheimer's disease in a subject, comprising:
- applying a transdermal patch to skin of the subject, wherein the transdermal patch comprises
- a composite backing layer comprised of (i) a first layer comprised of a polymer fabric or a polymer film having a stretchability of at least 5% in at least one direction;
- (ii) a second layer comprised of one or more adhesive polymers;
- and (iii) a third layer comprised of one or more polymer films;
- wherein the first and second layers are in contact and the second and third layers are in contact, and wherein the third layer comprises cuts formed at least partially through the layer;
- and
- an adhesive matrix drug layer laminated to the third layer, the adhesive matrix drug layer comprising a drug.
4 more elements
Dependencies are inferred from the claim text.