Multicompartment system of nanocapsule-in-nanocapsule type, for encapsulation of a lipophilic and hydrophilic compound, and the related production method

A multicompartment system of nanocapsule-in-nanocapsule type, in a form of water-in-oil-in-water double emulsion, for concurrent delivery of hydrophilic and lipophilic compounds, the multicompartment system comprising:

• a) a liquid oil core for transport of a lipophilic compound, containing oil selected from the group including:
• oleic acid, isopropyl palmitate, fatty acids, natural extracts and oils, such as corn oil, linseed oil, soybean oil, argan oil, or their mixtures;
• beneficially oleic acid;
• b) a capsule or many capsules with aqueous core, embedded in an oil core, for transport of a hydrophilic compound;
• c) a stabilizing shell for both the capsule with oil core and the inner capsule with water core, consisting of a hydrophobically modified polysaccharide selected from a group comprising:
• derivatives of chitosan, oligochitosan, dextran, carrageenan, amylose, starch, hydroxypropyl cellulose, pullulan and glycosaminoglycans, hyaluronic acid, heparin sulfate, keratan sulfate, heparan sulfate, chondroitin sulfate, dermatan sulfate;
• beneficially derivatives of hyaluronic acid;
• d) outer capsule with a diameter below 1 μm, stable in aqueous solution;
• and
• e) active substance.