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AssigneesThe Jackson Laboratory, Indiana University Research and Technology Corporation, Sage Bionetworks
InventorsGareth Howell, Gregory Carter, Michael Sasner, Stacey Rizzo, Harriet Williams, Bruce Lamb, Paul Territo, Adrian Oblak, Ben Logsdon, Lara Mangravite, Leah Graham
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The present disclosure provides a genetically modified mouse comprising a genomic nucleic acid encoding human APOE4, a genomic nucleic acid encoding mouse TREM2 modified to include a R47H substitution, and at least one genomic modification selected from the group consisting of: (a) a genomic nucleic acid encoding mouse ABCA7 modified to include an A 1541 G substitution; (b) a genomic nucleic acid encoding mouse APP modified to include G601R, F606Y, and R609H substitutions; (c) a genomic nucleic acid encoding mouse PLCG2 modified to include a M28L substitution; (d) a genomic nucleic acid encoding mouse MTHFR modified to include a A262V substitution; (e) an inactivated Ceacam1 allele; and (f) an inactivated Il1rap allele. Methods of producing the genetically modified mouse and methods of using the genetically modified mouse are also provided.
A genetically modified mouse comprising a genomic nucleic acid encoding human APOE4, a genomic nucleic acid encoding mouse TREM2 modified to include a R47H substitution, and at least one genomic modification selected from the group consisting of:
The genetically modified mouse of any one of claims 1-7, wherein the genetically modified mouse expresses the mouse TREM2 modified to include a R47H substitution.
A method of producing a genetically modified mouse, the method comprising
A method of producing a genetically modified mouse, the method comprising introducing into a mouse a genomic nucleic acid encoding human APOE4, a genomic nucleic acid encoding mouse TREM2 modified to include a R47H substitution, and at least one genomic modification selected from the group consisting of:
Dependencies are inferred from the claim text.