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US 2021/0195877 A1Published application
Non-human animals expressing exogenous terminal deoxynucleotidyltransferase
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsLynn Macdonald, Andrew J. Murphy, Chunguang Guo, Natasha Levenkova, Naxin Tu, John McWhirter, Vera Voronina, Faith Harris
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Abstract
Provided herein are methods and compositions related to non-human animals that express exogenous Terminal Deoxynucleotidyltransferase (TdT).
Claims30
A genetically modified non-human animal comprising in its genome:
- a nucleic acid sequence encoding an exogenous Terminal Deoxynucleotidyltransferase (TdT) operably linked to a transcriptional control element;
- and
- an immunoglobulin variable region comprising unrearranged human immunoglobulin variable region gene segments operably linked to an immunoglobulin constant region gene.
A genetically modified non-human animal comprising in its genome:
- a nucleic acid sequence encoding an exogenous Terminal Deoxynucleotidyltransferase (TdT) operably linked to a transcriptional control element;
- and
- a T cell receptor (TCR) variable region comprising unrearranged human TCR variable region gene segments operably linked to a TCR constant region gene.
A genetically modified non-human animal comprising in its genome:
- a nucleic acid sequence encoding an exogenous Terminal Deoxynucleotidyltransferase (TdT) operably linked to a transcriptional control element;
- and
- an immunoglobulin variable region comprising unrearranged human immunoglobulin variable region gene segments operably linked to a TCR constant region gene.
A genetically modified non-human animal ES cell comprising in its genome:
- a nucleic acid sequence encoding an exogenous Terminal Deoxynucleotidyltransferase (TdT);
- and
- (a) an immunoglobulin variable region comprising unrearranged human immunoglobulin variable region gene segments operably linked to an immunoglobulin constant region gene;
- (b) a T cell receptor (TCR) variable region comprising unrearranged human TCR variable region gene segments operably linked to a TCR constant region gene;
- or
- (c) an immunoglobulin variable region comprising unrearranged human immunoglobulin variable region gene segments operably linked to a TCR constant region gene.
3 more elements
Dependencies are inferred from the claim text.