Rapid nucleic acids separation and sample preparation via hollow-centered silica microsphere

A method for separating a nucleic acid from a sample, the method comprising:

• (a) contacting a sample lysate with a plurality of nucleic-acid-capture microspheres to form a lysate dispersion;
• wherein the lysate dispersion comprises a lysate continuous phase and a particulate phase and wherein the particulate phase comprises the plurality of nucleic-acid-capture microspheres and an adsorbed nucleic acid obtained from the sample;
• (b) separating the lysate continuous phase from the particulate phase comprising the plurality of inorganic, nucleic-acid-capture microspheres and the adsorbed nucleic acid obtained from the sample;
• and
• (c) contacting the particulate phase with an eluent to form an eluate comprising the nucleic acid obtained from the sample.