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US 2021/0180035 A1Published application
COMPOSITIONS COMPRISING A MODIFIED GIcNAc-1-PHOSPHOTRANSFERASE AND METHODS OF USE THEREOF
AssigneeWashington University
InventorsStuart Kornfeld, Lin Liu, Wang Lee, Balraj Doray
Life of this patent
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Abstract
The disclosure provides a modified UDP-GlcNAc:Lysosomal Enzyme GlcNAc-1-phosphotransferase with enhanced ability to phosphorylate lysosomal enzymes and methods of use thereof.
Claims18
-38. (canceled)
A method to increase binding of a protein of interest to cell surface mannose 6-phosphate receptor (Man-6-P), the method comprising expressing a modified GlcNAc-1 -PT α/β subunit in a cell.
Dependencies are inferred from the claim text.