Tissue catalyzed growth of polymer as epithelial linings for therapy
AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
InventorsRobert S. Langer, Carlo Giovanni Traverso, Junwei Li, Thomas Wang, Ameya R. Kirtane, Yunhua Shi
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Abstract
The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the monomer, dopamine, polymerizes in vivo to form a polymer on a tissue. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.
Claims34
A method of forming a polymer in situ in a subject, the method comprising administering to a subject a composition comprising a monomer and an oxygen source, wherein the monomer and the oxygen source contact a catalyst endogenous to the subject and the catalyst polymerizes the monomer, wherein the monomer is dopamine, or a salt thereof, the oxygen source is hydrogen peroxide or urea hydrogen peroxide, and the endogenous catalyst is selected from a catalase or a peroxidase.
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A composition comprising dopamine, an oxygen source, and optionally a buffer.
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Dependencies are inferred from the claim text.