System and method for producing a multiparameter graphic indicator from an image of a histological section

Method for producing a multiparameter graphic indicator relative to a remodelling of the human or animal alveolar epithelium from a digital representation of a histological section of a pulmonary lobe, such a digital representation comprising an array of a determined number of pixels which describe one or more components having annular shapes, within the parenchyma of said lobe, each of said one or more components having a wall encircling a lumen, said method being implemented by a processing unit of a system for histological analysis, said system moreover comprising an output human-machine interface and a data memory, wherein said method comprises:

• estimating a quantity of interest relative to the morphology of each component identified in the digital representation of the histological section, said quantity of interest belonging to a set of quantities of interest comprising:
• i. the Feret diameter of the outer contour of the wall of a component;
• ii. a mean distance separating said outer contour from the inner contour, describing a mean thickness of the wall of a component;
• iii. the area described by said inner contour of a component, describing the area of the lumen thereof;
• iv. the area described by said outer contour of a component, describing the total area covered thereby;
• estimating a quantity of interest relative to the structure of the parenchyma of the lobe, said quantity of interest belonging to a set of quantities of interest comprising:
• i. a lobe density, corresponding to a ratio between a number of identified components in the digital representation of the histological section and the area of the lobe;
• ii. a void rate of the lobe, corresponding to a ratio between the sum of the areas of the respective lumina of the identified components in the digital representation and the area of the lobe;
• iii. a parenchyma rate, corresponding to the area described by the parenchyma with respect to the area of the lobe;
• producing, per estimated quantity of interest, a graphic representation thereof relative to a standard quantity of interest;
• and
• causing the joint graphic outputting of the graphic representations of said quantities of interest relative to the respective standard quantities of interest produced beforehand, by the output human-machine interface of the system.