Use of microneedle patch to promote hair growth
AssigneeNorth Carolina State University
InventorsZhen Gu, Ph.D., Guang Yang
Life of this patent
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Abstract
Compositions comprising polymeric networks comprising combinations of small molecule hair growth agents and natural products (e.g., vesicles, such as stem cell-derived exosomes) are described. The polymeric network can, for example, comprise keratin crosslinked via intermolecular disulfide bonds. Alternatively, the polymeric network can comprise keratin or a derivative thereof and another crosslinked hydrophilic polymer. Microneedles, microneedle arrays, and skin patches comprising the compositions are also described, as are methods of treating hair loss and/or promoting hair growth using the microneedles, microneedle arrays and/or skin patches.
Claims20
A composition comprising:
- (a) a hydrophilic polymer network comprising keratin or a derivative thereof;
- (b) a natural product selected from the group consisting of vesicles, stem cells, and vesicle-derived molecules, optionally wherein the vesicles are exosomes, further optionally wherein the natural product comprises mesenchymal stem cell (MSC)-derived exosomes;
- and
- (c) a small molecule hair growth agent.
Dependencies are inferred from the claim text.