Compositions and methods for detecting albumin
AssigneeTournament BioVenture LLC
InventorShaoqiu ZHUO
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Abstract
The present disclosure provides a method for determining the amount of albumin in a sample. In one embodiment, the method involves treating the sample with an esterase inhibitor that selectively inhibits non-albumin esterase activity; combining the sample with a selective substrate of albumin, which has a carboxylic ester bond, so that the carboxylic ester bond is cleaved to generate a hydrolysate; detecting the amount of the hydrolysate generated in a period of time; and determining the amount of the albumin in the sample based on the amount of the hydrolysate in the period of time.
Claims11
A method for determining the amount of albumin in a sample, the method comprising:
- treating the sample with an esterase inhibitor that selectively inhibits non-albumin esterase activity;
- combining the sample with a selective substrate of albumin, which has a carboxylic ester bond, so that the carboxylic ester bond is cleaved to generate a hydrolysate;
- detecting the amount of the hydrolysate generated in a period of time;
- and
- determining the amount of the albumin in the sample based on the amount of the hydrolysate in the period of time.
Dependencies are inferred from the claim text.