Manufacture of porous glass and glass-ceramic particulate structures by gel casting
AssigneeSynthera Biomedical Private Limited
InventorsAmol Vasudeo CHAUDHARI, Nilay Jayant LAKHKAR
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Abstract
The invention discloses porous, bioactive glass and glass ceramic morsels or pellets to be used as tissue graft substitute materials and processes for obtaining the same wherein the bioactive glass and glass ceramic morsels or pellets are made up of natural agents like phosphate, calcium, sodium and other elements which are not alien to the human or animal body. The said preparation process encompasses various steps like quenching sintering, foaming, and sol-gel casting which render the glass morsels or pellets unique bioactivity and enhanced porosity which may facilitate tissue repair and augmentation during tissue graft replacement.
Claims28
A process for preparation of porous, bioactive and biocompatible material having a particle size in the range of 200 μm to 2500 μm, said process comprising:
- a. melting an admixture comprising a phosphorous compound, a calcium compound and a sodium compound and at least one other compound,
- said at least one other compound being an oxide of an element selected from a group including titanium, boron, potassium, magnesium, strontium, iron, copper, aluminum zinc, silver, gallium and cobalt,
- b. quenching said melted admixture in air or in water, followed by cooling said admixture to obtain a cooled admixture,
- c. crushing and sieving the cooled admixture to obtain a powder comprising particles having a size in the range of 5 μm to 50 μm,
- d. converting said powder into a gel, and casting said gel in a mold, cutting blocks of the cast gel and drying said gel blocks,
- e. sintering said dried gel blocks by uniformly increasing a temperature to reach a first temperature threshold and further to reach to a second temperature threshold, and further comprises holding the temperature at said first and second temperature thresholds followed by cooling the gel blocks to room temperature, and
- f. crushing and sieving said sintered gel blocks to obtain the porous, bioactive and biocompatible material having a particle size in the range of 200 μm to 2500 μm.
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The process of claim 25, wherein said second temperature threshold is 625° C.
A composition for a porous, bioactive and biocompatible material, said composition comprising:
- admixture comprising a mixture of a phosphorous compound, a calcium compound and a sodium compound and at least one other compound being an oxide of an element selected from a group including titanium, boron, potassium, magnesium, strontium, iron, copper, aluminium, zinc, silver, gallium and cobalt, characterized in that said material comprises particles having an average particle size in the range of 200 μm to 2500 μm, and having a pore size in the range of 10 μm to 300 μm.
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Dependencies are inferred from the claim text.