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US 2021/0145984 A1Published application
Ros-responsive microneedle patch for acne vulgaris treatment
AssigneeNorth Carolina State University
InventorsZhen Gu, Yuqi Zhang
Life of this patent
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Abstract
A composition comprising a bioresponsive (e.g., reactive oxygen species (ROS)-responsive), antibiotic- and/or absorbent-loaded polymeric network is described. In some cases, the composition can release the antibiotic loaded therein in response to ROS or another stimulus related to inflammation. Microneedles, microneedle arrays, and skin patches comprising the composition are also described, as well as methods of treating acne or other inflammatory/infectious skin conditions.
Claims46
A composition comprising:
- (a) a biocompatible polymeric network comprising (i) a biodegradable polymer, optionally wherein the biodegradable polymer comprises a polyester, or (ii) a crosslinked hydrophilic polymer, wherein said crosslinked hydrophilic polymer comprises a hydrophilic polymer crosslinked via a plurality of bioresponsive linkages;
- and
- (b) one or more of (iii) an antibiotic or antibiotic-loaded carrier embedded in the biocompatible polymeric network, and (iv) an absorbent additive, optionally diatomaceous earth.
A reactive oxygen species (ROS)-responsive antibiotic hydrogel comprising:
- (a) crosslinked hydrophilic polymer, wherein said crosslinked hydrophilic polymer comprises a hydrophilic polymer, optionally PVA or a copolymer thereof, crosslinked via a plurality of ROS-responsive linkages, wherein each of the ROS-responsive linkages comprises one or more bond that is cleavable in the presence of a ROS, optionally wherein the ROS is a peroxide;
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- (b) an antibiotic or antibiotic-loaded carrier embedded in the biocompatible polymeric network, optionally wherein the antibiotic is clindamycin.
A microneedle array comprising:
- (a) a plurality of microneedles comprising a biocompatible polymeric network comprising (i) a biodegradable polymer, optionally wherein the biodegradable polymer comprises a polyester, or (ii) a crosslinked hydrophilic polymer, wherein said crosslinked hydrophilic polymer comprises a hydrophilic polymer crosslinked via a plurality of bioresponsive linkages, optionally wherein each of said plurality of microneedles has a length of between about 20 and about 1000 micrometers, further optionally wherein each of the plurality of microneedles has a length of about 600 micrometers and/or a base diameter of about 300 micrometers;
- (b) a base layer to which a base of each of said plurality of microneedles is attached and wherein said base layer comprises a crosslinked polymer, optionally wherein the crosslinked polymer is methacrylated hyaluronic acid;
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- (c) an absorbent, optionally wherein the absorbent is present in the base layer.
1 more element
Dependencies are inferred from the claim text.