Compounds and synthetic methods for the preparation of retinoid x receptor-specific retinoids

A method of synthesizing a compound of Formula II

• by treating a compound of Formula I
• wherein R1 is C1-20-alkyl;
• C1-20-alkyl substituted with one or more substituents independently selected from —NH2, —NH(C1-10-alkyl), —N(C1-10-alkyl)(C1-10-alkyl), —OH, halogen, —C1-10-alkyl, —C1-10-haloalkyl, —O—(C1-10-alkyl), or —O—(C1-10-haloalkyl);
• C1-20-alkenyl;
• C1-20-alkenyl substituted with one or more substituents independently selected from —NH2, —NH(C1-10-alkyl), —N(C1-10-alkyl)(C1-10-alkyl), —OH, halogen, —C1-10-alkyl, —O—(C1-10-alkyl), or —O—(C1-10-haloalkyl);
• C6-14-aryl;
• or C6-14-aryl substituted with one or more substituents independently selected from —NH2, —NH(C1-10-alkyl), —N(C1-10-alkyl)(C1-10-alkyl), —OH, halogen, —C1-10-alkyl, —O—(C1-10-alkyl), or —O—(C1-10-haloalkyl),
• or a salt, hydrate, or solvate thereof,
• with potassium tert-butoxide (KOt-Bu) forming a mixture, and then adding to the mixture a Compound 32, having the structure
• or a salt, hydrate, or solvate thereof,
• such that the compound of Formula II, or a salt, hydrate, or solvate thereof, is prepared.