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US 2021/0138084 A1Published application
Conjugates of active pharmaceutical ingredients
AssigneeThe Regents of the University of California
InventorsYuanpei LI, Xiangdong XUE, Yee HUANG, Zhao MA
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Abstract
The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.
Claims45
A compound of Formula I:
- X-(L)-Y
- wherein
- X is a hydrophilic therapeutic agent;
- L is absent or is a linker;
- and
- Y is a photo-active compound comprising a porphyrin or analog thereof, or a hydrophobic therapeutic agent,
- where the compound is other than doxorubicin-10-hydroxycamptothecin and irinotecan-chlorambucil.
4 more elements
Dependencies are inferred from the claim text.