Formulations and methods of use for alpha connexin c-terminal (act) peptides
AssigneeFirststring Research, Inc.
InventorGautam GHATNEKAR
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Abstract
This invention relates to a topical gel drug product preparation containing a composition comprising an isolated polypeptide having a carboxy-terminal amino acid sequence of an alpha connexin (ACT peptide), peptide stabilizers, excipients, buffering agents, and the like. A formulation and preparation steps are disclosed for the manufacturing of a stable, elegant, and pourable topical gel. The resulting formulation possesses long term stability suitable for aesthetic as well as therapeutic applications including the prevention of scaring and accelerated healing of wounds. Methods for treatment of chronic wounds, including chronic ulcers, are also provided.
Claims23
A method of treating a chronic wound in a subject, comprising administering to the subject a topical formulation comprising at least one alpha connexin polypeptide, wherein the formulation is administered in a dosing regimen effective for the treatment of the chronic wound.
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A method of treating a chronic wound in a subject, comprising administering to the subject a topical formulation comprising at least one alpha connexin polypeptide in addition to standard of care compression therapy, wherein the chronic wound is healed at a faster rate and/or increased frequency than achieved with standard of care compression therapy alone.
A composition for treating a chronic wound in a subject, comprising at least one alpha connexin polypeptide and a carrier.
Dependencies are inferred from the claim text.