Psma-targeted radiopharmaceutical for diagnosing and treating prostate cancer

2:

• The compound, the stereoisomer thereof, the hydrate thereof, or the pharmaceutically acceptable salt thereof according to claim 1, wherein:
• L1 is —(CH2)a—, wherein a is an integer of 1˜6;
• U is a bond, or —C(O)—;
• R1 is hydrogen, or -L5-CO2H, wherein L5 is —(CH2)b—, wherein b is an integer of 1˜4;
• X is a bond, or —C(O)—;
• W is a bond, or -NA1-, A1 is hydrogen, or —(CH2)c-pyridyl, wherein c is an integer of 0˜1;
• L2 is a bond, or —(CH2)d—, wherein d is an integer of 1˜6;
• Tz is a bond,
• L3 is C1-10 straight or branched alkylene, wherein one or more carbon atoms in alkylene can be replaced by oxygen atoms;
• L4 is —(CH2)e—, wherein e is an integer of 2˜4;
• n is an integer of 0˜1;
• R2 is hydrogen, C1-3 straight or branched alkyl, or halogen;
• Y is oxygen or sulfur;
• Z is a chelator including a radioactive metal, wherein the radioactive metal is Ga-68, Cu-64, Cu-67, Y-90, Sc-47, In-111, Sn-117m, Lu-177, Bi-212, Bi-213, Pb-212, Rd-223, or Ac-225, and the chelator is

3:

• The compound, the stereoisomer thereof, the hydrate thereof, or the pharmaceutically acceptable salt thereof according to claim 1, wherein:
• L1 is —(CH2)a—, wherein a is an integer of 2˜4;
• U is a bond, or —C(O)—;
• R1 is hydrogen, or -L5-CO2H, wherein L5 is —(CH2)b—, wherein b is an integer of 1˜2;
• X is a bond, or —C(O)—;
• W is a bond, or -NA1-, wherein A1 is hydrogen or pyridyl;
• L2 is a bond, or —(CH2)d—, wherein d is an integer of 1˜2;
• Tz is a bond,
• L3 is C1-8 straight alkylene, wherein one or more carbon atoms in alkylene can be replaced by oxygen atoms;
• L4 is —(CH2)3—;
• n is an integer of 0˜1;
• R2 is hydrogen, methyl or halogen;
• Y is oxygen;
• Z is a chelator including a radioactive metal, wherein the radioactive metal is Ga-68, Cu-64, or Lu-177, and the chelator can be

5:

• A compound represented by formula 2, a stereoisomer thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof:
• In formula 2,
• L1 is —(CH2)a—, wherein a is an integer of 1˜8;
• U is a bond, or —C(O)—;
• R1 is hydrogen or -L5-CO2H, wherein L5 is —(CH2)b—, wherein b is an integer of 1˜6;
• X is a bond, or —C(O)—;
• W is a bond or -NA1-, and A1 is hydrogen or —(CH2)c-pyridyl, wherein c is an integer of 0˜3;
• L2 is a bond or —(CH2)d—, wherein d is an integer of 1˜8;
• Tz is a bond,
• L3 is C1-12 straight or branched alkylene, wherein one or more carbon atoms in alkylene can be replaced by oxygen atoms;
• L4 is —(CH2)e—, wherein e is an integer of 1˜6;
• n is an integer of 0˜1;
• R2 is hydrogen, C1-5 straight or branched alkyl, or halogen;
• Y is oxygen or sulfur;
• Z′ is a chelator, and the chelator is

6:

• The compound, the stereoisomer thereof, the hydrate thereof, or the pharmaceutically acceptable salt thereof according to claim 5, wherein:
• L1 is —(CH2)a—, wherein a is an integer of 1˜6;
• U is a bond, or —C(O)—;
• R1 is hydrogen or -L5-CO2H, wherein L5 is —(CH2)b—, wherein b is an integer of 1˜4;
• X is a bond, or —C(O)—;
• W is a bond or -NA1-, and A1 is hydrogen or —(CH2)c-pyridyl;
• L2 is a bond or —(CH2)d—, wherein d is an integer of 1˜6;
• Tz is
• L3 is C1-10 straight or branched alkylene, wherein one or more carbon atoms in alkylene can be replaced by oxygen atoms;
• L4 is —(CH2)3—;
• n is an integer of 0˜1;
• R2 is hydrogen, C1-3 straight or branched alkyl, or halogen;
• Y is oxygen or sulfur;
• Z′ is a chelator, and the chelator is

7:

• The compound, the stereoisomer thereof, the hydrate thereof, or the pharmaceutically acceptable salt thereof according to claim 5, wherein:
• L1 is —(CH2)a—, wherein a is an integer of 2˜4;
• U is a bond, or —C(O)—;
• R1 is hydrogen or -L5-CO2H, wherein L5 is —(CH2)b—, wherein b is an integer of 1˜2;
• X is a bond, or —C(O)—;
• W is a bond or -NA1-, and A1 is hydrogen or pyridyl;
• L2 is a bond or —(CH2)d—, wherein d is an integer of 1˜2;
• Tz is a bond,
• L3 is C1-8 straight alkylene, wherein one or more carbon atoms in alkylene can be replaced by oxygen atoms;
• L4 is —(CH2)3—;
• n is an integer of 0˜1;
• R2 is hydrogen, methyl, or halogen;
• Y is oxygen;
• Z′ is a chelator, and the chelator is