Oligodendrocyte-specific promoter, mirna specific to plp1 gene,vector including said promoter and/or mirna, and pharmaceutical composition including said vector

An miRNA specific to a PLP1 gene, comprising a pair of nucleotide sequences consisting of an antisense sequence and a sense sequence, wherein the pair of nucleotide sequences is selected from the group consisting of pairs of an antisense sequence set forth in a left column of a table below and a sense sequence set forth in a corresponding row of a right column of the table.

• Antisense sequence
• Sense sequence
• AAAGGAAGAAGAAAGAGGCAG (SEQ ID NO:
• CTGCCTCTCTTCTTCCTTT (SEQ ID NO:
• 53)
• 52)
• AACACCAGGAGCCACACAACG (SEQ ID NO:
• CGTTGTGTCTCCTGGTGTT (SEQ ID NO:
• 55)
• 54)
• TTCCATGGGAGAACACCATAC (SEQ ID NO:
• GTATGGTGCTCCCATGGAA (SEQ ID NO:
• 57)
• 56)
• TGAGCAGGGAAACCAGTGTAG (SEQ ID NO:
• CTACACTGTTCCCTGCTCA (SEQ ID NO:
• 59)
• 58)
• AGGGCTTTCTGATTGACAGCC (SEQ ID NO:
• GGCTGTCACAGAAAGCCCT (SEQ ID NO:
• 61)
• 60)
• ACCCCAAAGAAACACAATCCA (SEQ ID NO:
• TGGATTGTTTCTTTGGGGT (SEQ ID NO:
• 63)
• 62)
• ACAAATGCAGCAATAAACAGG (SEQ ID NO:
• CCTGTTTAGCTGCATTTGT (SEQ ID NO:
• 65)
• 64)
• AATAGACTGGCAGGTGGTCCA (SEQ ID NO:
• TGGACCACGCCAGTCTATT (SEQ ID NO:
• 67)
• 66)
• AAAGAATGAGCTTGATGTTGG (SEQ ID NO:
• CCAACATCGCTCATTCTTT (SEQ ID NO:
• 69)
• 68)
• AGATACTCATAGTCTTGGTAG (SEQ ID NO:
• CTACCAAGTATGAGTATCT (SEQ ID NO:
• 71)
• 70)
• AGAAACACAATCCAGTGGCCA (SEQ ID NO:
• TGGCCACTATTGTGTTTCT (SEQ ID NO:
• 73)
• 72)
• AAATAGGTCTCAATTAGCTTT (SEQ ID NO:
• AAAGCTAAGAGACCTATTT (SEQ ID NO:
• 75)
• 74)
• AAGAAACACAATCCAGTGGCC (SEQ ID NO:
• GGCCACTGTTGTGTTTCTT (SEQ ID NO:
• 77)
• 76)
• TAAACAGGTGGAAGGTCATTT (SEQ ID NO:
• AAATGACCCCACCTGTTTA (SEQ ID NO:
• 79)
• 78)
• TTGTAGTCGCCAAAGATCTGC (SEQ ID NO:
• GCAGATCTGGCGACTACAA (SEQ ID NO:
• 81)
• 80)
• AATTAGAGCCTCCATTCCTTT (SEQ ID NO:
• AAAGGAATAGGCTCTAATT (SEQ ID NO:
• 83)
• 82)
• TTAAGGACGGCAAAGTTGTAA (SEQ ID NO:
• TTACAACTGCCGTCCTTAA (SEQ ID NO:
• 85)
• 84)
• TTTAAGGACGGCAAAGTTGTA (SEQ ID NO:
• TACAACTTCCGTCCTTAAA (SEQ ID NO:
• 87)
• 86)
• ATGTCTTTGGGACTCTGACTC (SEQ ID NO:
• GAGTCAGACCCAAAGACAT (SEQ ID NO:
• 89)
• 88)
• TATCTATCCTGTGTCTACCAG (SEQ ID NO:
• CTGGTAGACAGGATAGATA (SEQ ID NO:
• 91)
• 90)
• AAATTACTTTCTGATCCTCAG (SEQ ID NO:
• CTGAGGATGAAAGTAATTT (SEQ ID NO:
• 93)
• 92)
• TCTAACAAGCCCATGTCTTTG (SEQ ID NO:
• CAAAGACAGGCTTGTTAGA (SEQ ID NO:
• 95)
• 94)
• AATTACTTTCTGATCCTCAGG (SEQ ID NO:
• CCTGAGGAAGAAAGTAATT (SEQ ID NO:
• 97)
• 96)
• AGTAAATGTACACAGGCACAG (SEQ ID NO:
• CTGTGCCTGTACATTTACT (SEQ ID NO:
• 99)
• 98)
• TAAGTAAGGTTGGCTGAGTTA (SEQ ID NO:
• TAACTCAGAACCTTACTTA (SEQ ID NO:
• 100)
• 101)
• TTCTGTGGGTGAAAGATCCTT (SEQ ID NO:
• AAGGATCTCACCCACAGAA (SEQ ID NO:
• 102)
• 103)
• AGAAGATGCTGACAACACCCT (SEQ ID NO:
• AGGGTGTTCAGCATCTTCT (SEQ ID NO:
• 104)
• 105)
• AATTGTAGCCGGCTGGCTAGT (SEQ ID NO:
• ACTAGCCACGGCTACAATT (SEQ ID NO:
• 106)
• 107)
• AGATTTGGGCAAACGCTCTTA (SEQ ID NO:
• TAAGAGCGTGCCCAAATCT (SEQ ID NO:
• 108)
• 109)
• ATTCTACGCTCCCTTATGCTG (SEQ ID NO:
• CAGCATAAGAGCGTAGAAT (SEQ ID NO:
• 110)
• 111)
• TGGTAATAGAGAGACCAGAAT (SEQ ID NO:
• ATTCTGGTCTCTATTACCA (SEQ ID NO:
• 112)
• 113)
• TATAGATGGCAAGAGGACCAA (SEQ ID NO:
• TTGGTCCTTGCCATCTATA (SEQ ID NO:
• 114)
• 115)
• AAACCAGTGTAGCTGCAGCCC (SEQ ID NO:
• GGGCTGCATACACTGGTTT (SEQ ID NO:
• 116)
• 117)