Extracellular domain of alpha subunit of ige fc receptor, pharmaceutical composition comprising same and method for producing same
AssigneeGl INNOVATION, INC.
InventorsYoung Chul SUNG, Zungyoon YANG
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Abstract
The present invention provides a polypeptide dimeric protein containing two monomers, each of which contains an extracellular domain (FcεRIa-ECD) of an alpha subunit of an IgE Fc receptor. The dimeric protein according to the present invention has advantages that an excellent binding ability to IgE is exhibited as compared with a conventional therapeutic agent containing an anti-IgE antibody, and less other side effects are exhibited due to lack of ADCC and CDC functions. Thus, the dimeric protein can be applied to a medical product for treating or preventing an IgE-mediated allergic disease.
Claims20
A polypeptide dimer, comprising:
- two monomers, each of which contains an extracellular domain (FcεRIα-ECD) of an alpha subunit of an IgE Fc receptor,
- wherein the monomer contains a modified Fc region, and
- the modified Fc region and the FcεRIα-ECD are linked via a hinge.
Dependencies are inferred from the claim text.