Substituted indole ether compounds

A compound of Formula (I)

• N-oxide, or a salt thereof, wherein:
• G is
• (iv) a 9-membered heterocyclic ring selected from:
• (v) 10-membered heterocyclic ring selected from:
• A is -L-R6;
• L is a bond, —(CRxRx)1-2—, —(CRxRx)1-2CRx(OH)—, —(CRxRx)1-2O—, —CRxRxC(O)—, —CRxRxC(O)NRx(CRxRx)0-4—, —CRxRxNRxC(O)CRxRx)0-4, or —CRxRxNRxC(O)CRxRx)0-4—;
• R1 is H, Cl, —CN, C1-4 alkyl, C1-3 fluoroalkyl, C1-3 hydroxyalkyl, C1-3 hydroxy-fluoroalkyl, —CRv═CH2, C3-6 cycloalkyl, —CH2(C3-6 cycloalkyl), —C(O)O(C1-3 alkyl), or tetrahydropyranyl;
• each R2 is independently halo, —CN, —OH, —NO2, C1-4 alkyl, C1-2 fluoroalkyl, C1-2 cyanoalkyl, C1-3 hydroxyalkyl, C1-3 aminoalkyl, —O(CH2)1-2OH, —(CH2)0-4O(C1-4 alkyl), C1-3 fluoroalkoxy, —(CH2)1-4O(C1-3 alkyl), —O(CH2)1-2OC(O)C1-3 alkyl), —O(CH2)1-2NRxRx, —C(O)O(C1-3 alkyl), —(CH2)1-2C(O)NRyRy, —C(O)NRx(C1-5 hydroxyalkyl), —C(O)NRx(C2-6 alkoxyalkyl), —C(O)NRx(C3-6 cycloalkyl), —NRyRy, —NRy(C1-3 fluoroalkyl), —NRy(C1-4 hydroxyalkyl), —NRxCH2(phenyl), —NRxS(O)2(C3-6 cycloalkyl), —NRxC(OXC1-3 alkyl), —NRxCH2(C3-6 cycloalkyl), —(CH2)0-2S(O)2(C1-3 alkyl), —(CH2)0-2(C3-6 cycloalkyl), —(CH2)0-2(phenyl), morpholinyl, dioxothiomorpholinyl, dimethyl pyrazolyl, methylpiperidinyl, methylpiperazinyl, amino-oxadiazolyl, imidazolyl, triazolyl, or —C(O)thiazolyl);
• R2a is C1-6 alkyl, C1-3 fluoroalkyl, C1-6 hydroxyalkyl, C1-3 aminoalkyl, —(CH2)0-4O(C1-3 alkyl), C3-6 cycloalkyl, —(CH2)1-3C(O)NRxRx, —CH2(C3-6 cycloalkyl), —CH2(phenyl), tetrahydrofuranyl, tetrahydropyranyl, or phenyl;
• each R2b is independently H, halo, —CN, —NRxRx, C1-6 alkyl, C1-3 fluoroalkyl, C1-3 hydroxyalkyl, C1-3 fluoroalkoxy, —(CH2)0-2O(C1-3 alkyl), —(CH2)1-3C(O)NRxRx, —(CH2)1-3(C3-6 cycloalkyl), —C(O)O(C1-3 alkyl), —C(O)NRx(C1-3 alkyl), —CRx═CRxRx, or —CRx═CH(C3-6 cycloalkyl);
• R2c is R2a or R2b;
• R2d is R2a or R2b;
• provided that one of R2c and R2d is R2a, and the other of R2c and R2d is R2b;
• each R5 is independently F, Cl, —CN, C1-3 alkyl, C1-2 fluoroalkyl, or —OCH3;
• R6 is:
• (i) —NRxRx, —CRxRxC(O)NRx(CRxRx)1-3OH, —CRxRxC(O)NRx(CRxRx)1-2NRxRx, or —CRxRxC(O)NRx(CRxRx)1-2CHFCRxRxOH;
• or
• (ii) azabicyclo[3.2.1]octanyl, azaspiro[5.5]undecanyl, azetidinyl, C3-6 cycloalkyl, diazabicyclo[2.2.1]heptanyl, diazaspiro[3.5]nonanyl, imidazolyl, morpholinyl, tetrahydrofuranyl, tetrahydropyranyl, octahydrocyclopenta[c]pyrrolyl, phenyl, piperazinyl, piperidinyl, pyrrolidinyl, pyridinyl, or quinuclidinyl, each substituted with zero to 3 R6a;
• each R6a is independently F, Cl, —OH, —CN, C1-6 alkyl, C1-4 fluoroalkyl, C1-6 hydroxyalkyl, —(CH2)1-2O(C1-3 alkyl), —NRxRx, —(CH2)1-2NRxRx, —(CRxRx)1-2S(O)2(C1-3 alkyl), —(CRxRx)1-2C(O)ORy, —(CRxRx)1-2C(O)NRxRx, —C(O)CRxRx)1-2NRxRx, —(CRxRx)1-2(phenyl), oxetanyl, morpholinyl, tetrahydrofuranyl, tetrahydropyranyl, azetidinyl, pyrrolidinyl, piperidinyl, isopropylpiperidinyl, isobutylpiperidinyl, piperazinyl, or —O(piperidinyl);
• Rv is H, C1-2 alkyl, or C1-2 fluoroalkyl;
• each Rx is independently H or —CH3;
• each Ry is independently H or C1-6 alkyl;
• n is zero, 1, or 2;
• and
• p is zero, 1, 2, 3, or 4.