Systems and methods for integrating sensors with pumps in a microfluidic device

A method, comprising:

• receiving, by a controller device in electrical communication with a plurality of probes, an identification of a well of a well plate for a measurement;
• selecting, by the controller device, a probe of the plurality of probes that corresponds to the identification of the well for measurement;
• establishing, by the controller device via one or more switches, a connection from a sensor to a source electrode and a respective sense electrode of the probe;
• determining, by the controller device, a measurement of a fluid sample in the well using the sensor;
• and
• storing, by the controller device, the measurement in a memory.

A system, comprising:

• a plurality of current source electrodes of a first respective plurality of pump sippers disposed within a first respective plurality of wells in a well plate;
• a plurality of voltage sense electrodes of a second respective plurality of pump sippers disposed within a second respective plurality of wells, the second respective plurality of wells coupled to the first plurality of wells via a channel comprising a solution including cells;
• and
• a controller device configured to:
• route an electric current through the cells in the channel using a first current source electrode and a second current source electrode of the plurality of current source electrodes;
• measure a voltage level across the cells caused in part by the electric current;
• determine a parameter of the solution using the voltage level;
• and
• actuate a pump of one of the first plurality of pump sippers or the second plurality of pump sippers.