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US 2021/0069352 A1Published application
Iodine-based particles
AssigneeNanoprobes, Inc.
InventorJames F. HAINFELD
Life of this patent
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Abstract
Described herein are iodine-based particles which can be used as contrast agents for x-ray radiology. Also described herein are methods, software modules and hardware modules for imaging iodine-based particles.
Claims20
An iodine nanoparticle which is a reaction product of functionalized triiodobenzene, linking monomers, and biocompatible polymers;
- wherein said functionalized triiodobenzene, said linking monomers, and said biocompatible polymers are covalently cross-linked resulting in the structure of said nanoparticle being non-dendritic, non-uniform, and non-linear;
- wherein said nanoparticle has a polydispersity index of about 0.5 or less;
- wherein said nanoparticle has sufficient iodine density to be imaged by an imaging device following administration to a subject;
- and
- wherein said nanoparticle provides for an extended blood half-life.
2 more elements
An encapsulated iodine particle comprising a hydrophobic core and an amphipathic encapsulating layer wherein said hydrophobic core consists of a hydrophobic iodine nanoparticle, a hydrophobic triiodobenzene monomer or a hydrophobic triiodobenzene dimer;
- wherein said iodine nanoparticle is a reaction product of functionalized triiodobenzene and linking monomers;
- wherein said functionalized triiodobenzene and said linking monomers are covalently cross-linked resulting in the structure of said iodine nanoparticle being non-dendritic, non-uniform, and non-linear;
- wherein said iodine nanoparticle has a polydispersity index of about 0.5 or less;
- wherein said iodine nanoparticle has sufficient iodine density to be imaged by an imaging device following administration to a subject;
- and
- wherein said iodine nanoparticle provides for an extended blood half-life.
3 more elements
Dependencies are inferred from the claim text.