Antibody-drug conjugate comprising antibody against human ror1 and use for the same

An antibody conjugate of the General Formula I, or a pharmaceutically acceptable salt thereof:

• Ab-(X)y [General Formula I]
• wherein:
• Ab is an anti-ROR1 antibody, or an antigen-binding fragment thereof,
• the antibody or antigen-binding fragment thereof comprises:
• a heavy chain variable region comprising a CDRH1 comprising the amino acid sequence of any one of SEQ ID NOs. 1-5;
• a CDRH2 comprising the amino acid sequence of any one of SEQ ID NOs. 6-13 and 96;
• and a CDRH3 comprising the amino acid sequence of any one of SEQ ID NOs. 14-21 and 97;
• and
• a light chain variable region comprising a CDRL1 comprising the amino acid sequence of any one of SEQ ID NOs. 22-29;
• a CDRL2 comprising the amino acid sequence of any one of SEQ ID NOs. 30-37;
• and a CDRL3 comprising the amino acid sequence of any one of SEQ ID NOs. 38-42;
• each X is independently selected from a moiety that comprises at least one active agent and a linker, wherein the linker couples Ab to the at least one active agent;
• wherein the linker links Ab and the at least one active agent;
• and
• y is an integer from 1 to 20.